An Indian takeaway store in Adelaide’s southern suburbs has become a victim to a suspected arson attack.

Dial a Curry on Marion Road, South Plympton, was ablaze when emergency services arrived at the scene about 4:30am on Wednesday.

Flames were coming out of the roof and the building deemed too ‘dangerous’ as the ceiling began to collapse.

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The owners of the business raced to the store, which could not be saved.

Owner Mohit Gupta told 7NEWS that he is in disbelief.

“I can’t believe what happened. I received a call from police around 5 o’clock (and) they said the whole building set on fire,” he said.

MFS firefighter Phill Ross told 7NEWS that crews entered safely through the back of the building.

“In the front it was too dangerous to get in,” he said.

“Our main operation was aerial firefighting.”

It took firefighters over an hour to bring the inferno under control.

CCTV footage shows two men running away just as the fire took hold.

Moments earlier, the men were seen on the restaurant’s roof, where it is believed the blaze started.

Gupta’s brother, Rohit, believes the CCTV cameras were tampered with before the fire.

“The first camera on the building, they break the camera,” he told 7NEWS.

“The second one, they damaged the camera. The third one, they turned the camera face down.”

A dozen workers will now be moved to Dial a Curry’s two other stores at Enfield and Croydon Park.

Damage has been estimated at about $400,000.