Two people have been injured in a serious multi-vehicle crash that sent one car crashing through a house.

The collision happened on Wiley Ave, Greenacre, in Sydney’s southwest, at about 12.50am on Sunday.

WATCH THE VIDEO ABOVE: Two injured in serious multi-vehicle collision in Greenacre

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One of the cars veered off the road following the collision and crashed into a house, rupturing gas and water lines.

It’s unclear if anyone was home at the time.

The 26-year-old female driver of a ute was taken to hospital with serious leg injuries in a stable condition.

A second driver, a 45-year-old man, was also taken to hospital in a stable condition.

His passengers – a 37-year-old woman and three children aged 15, 13 and five – were not injured.

The driver of the third car, a 24-year-old man, was taken to St George Hospital in a stable condition for treatment and mandatory testing.

All three vehicles suffered extensive damage in the crash and there was debris scattered across the road.

Exactly what caused the collision is unclear.

Those involved in the crash lined the sides of the street as emergency services workers attended to them.

Anyone who witnessed the crash or has any dashcam footage is urged to call Bankstown police or Crime Stoppers.