A toddler is fighting for life following a horrific crash on a Victorian road.

The car they were travelling in crashed into a tree on Yan Yean Rd in Yarrambat, 24km northeast of Melbourne’s CBD, about 1.45pm on Tuesday.

The woman was taken to hospital with serious injuries and the toddler is in a critical condition.

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The investigation is ongoing.

Yan Yean Road has been closed in both directions between Bannons Lane and Ironbark Road following the crash, with drivers urged to avoid the area.

Police are calling on anyone who witnessed the crash, or who may have CCTV or dashcam footage, to come forward.