Thousands of state school teachers will walk off the job next Wednesday in a major escalation of a pay dispute with the state government.

Queensland Teachers’ Union (QTU) members have voted overwhelmingly in favour of a 24-hour strike on Wednesday, August 6.

WATCH THE VIDEO ABOVE: Queensland teachers to strike for 24 hours

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A ballot was sent to more than 48,000 members of the QTU, asking them if they were in favour of strike action.

The result was a resounding 95 per cent in favour.

“This is just the beginning. We are united and we are serious,“ QTU president Kate Ruttiman said.

It is the first time in 16 years Queensland teachers and school leaders have taken such action.

Union leaders say the strike is a sign of how “extreme” the situation has become.

“Valuing teachers is an investment in tomorrow, ensuring that the best possible people are attracted to the profession and the great teachers we have feel respected enough to stay,” a QTU statement said.

“We have bargained in good faith. We have been patient. But the bell has well and truly gone on the government’s chance to show educators we are valued.”

Parents are already preparing for the disruption.

“We’re lucky enough to be able to keep them at home,” one parent told 7NEWS.

Another said: “Hopefully send them to the grandparents.”

Education Queensland said contingency plans are being developed but warns staffing will be limited to teachers who are not union members.

The state government is grappling with an industrial relations storm.

Teachers are set to strike, nurses are threatening further action, and now police could join the fight.

The Police Union has secured a record-breaking pay deal worth $562 million, including an 8 per cent wage increase over three years and bonuses of up to $8000.

However, there is little benefit for detectives and senior officers.

They remain unconvinced and have warned they may vote it down.

Firefighters are also preparing to enter the bargaining fray, adding more pressure to a government already negotiating on multiple fronts.