A bilateral ceasefire “is now in effect” in the Middle East, US President Donald Trump has announced, signalling a pause to the deadly hostilities.

It comes shortly after at least four people were killed in Beersheba in southern Israel after Iran launched a missile barrage .

Trump took to his social media platform with the update just as media in both Israel and Iran began reporting fighting would be suspended.

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“THE CEASEFIRE IS NOW IN EFFECT. PLEASE DO NOT VIOLATE IT!” Trump said.

In its first official comment on the ceasefire, Israel said it had achieved its objectives “and much more” after more than a week of strikes on Iran.

“Israel has eliminated an immediate and dual existential threat — both in the nuclear domain and in the realm of ballistic missiles,” the office of PM Benjamin Netanyahu said in a statement.

“Additionally, the IDF has achieved full aerial control over Tehran’s skies, dealt a severe blow to the Iranian military leadership, and destroyed dozens of key regime targets in Iran.”

Israel thanked the US for its support and said it would “respond forcefully to any violation of the ceasefire” by Iran.

Iran’s semi-official SNN news agency reported on Tuesday that Tehran fired its last round of missiles before the ceasefire came into effect.

An Iranian official earlier confirmed that Tehran had agreed to a ceasefire, but the country’s foreign minister said there would be no cessation of hostilities unless Israel stopped its attacks.

Abbas Araqchi said early on Tuesday that if Israel stopped its “illegal aggression” against the Iranian people no later than 4am Tehran time (10.30am AEST) on Tuesday, Iran had no intention of continuing its response afterwards.

Military analysts believe the ceasefire can hold for at least a short period of time because Iran needs time to regroup.

Retired Air Force Colonel Cedric Leighton also said Israel had achieved a lot of its goals, including hitting Iranian nuclear facilities and decimating its air defence system.

“It’s very possible that it will hold, at least for a while,” Leighton told CNN.

The ceasefire came after the IDF reported multiple missile barrages had been launched from Iran in the early hours of Tuesday.

Israel’s military said six waves of missiles were launched by Iran and Israel’s national ambulance service said four people were killed in Beersheba.

Israel, joined by the United States on the weekend, has carried out attacks on Iran’s nuclear facilities, after alleging Tehran was getting close to obtaining a nuclear weapon.

Iran denies ever having a nuclear weapons program but Supreme Leader Ali Khamenei has said that if it wanted to, world leaders “wouldn’t be able to stop us”.

The Trump administration maintains its aim was solely to destroy Iran’s nuclear program, not to open a wider war.

Trump has cited intelligence reports that Iran was close to building a nuclear weapon, without elaborating.

- With Reuters