A landmark property established by Australian wine pioneer Robert Oatley is back on the market for the first time in 15 years.

Rosemount Estate at Denman, in the Hunter Valley, is jointly listed with Colliers Newcastle, Knight Frank Newcastle and McGrath Upper Hunter via an expressions of interest campaign.

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The 568-acre site comprises large-scale infrastructure, fertile farmland and hospitality facilities.

Matt Shaw, a partner at Knight Frank Newcastle, said the property's mix of assets makes it suitable for industries such as transport and logistics, agriculture, tourism, events and boutique manufacturing.

"Properties of this scale and diversity rarely come to market in the Hunter Valley," Mr Shaw said.

"516 Rosemount Road offers a rare chance to combine industrial, agricultural and tourism opportunities on a highly versatile site."

Mr Shaw said the site offers "exceptional" scope for commercial operations with multiple large-scale warehouses with temperature control and significant power capacity.

The property also has a private airstrip.

"We have had initial interest from hemp operators," he said.

"The other types of parties interested could be include mining, green energy, waste and recycling groups, and larger agri businesses, which have expressed interest in the past.

"The site offers a diverse range of uses because of the significant industrial infrastructure."

Additionally, a function centre, wedding and event facilities, a cellar door and three dwellings on-site are ideal for tourism and hospitality ventures.

Mr Shaw said the property's fertile rural land, with irrigation infrastructure and extensive Goulburn River frontage, adds further value to agricultural operations.

Sydney-based private investor Bob Wheeldon has owned the property since 2010.

"The winery itself hasn't been operational for quite some time," Mr Shaw said.

"The current owner has tenanted the property in the past and maintained the asset well.

"It is very well-kept and has undergone improvements with the cellar door, and the venue has recently been used for weddings."

Mr Shaw said pricing is being guided by the market.

"We are running a genuine expressions of interest campaign given the scale of the property and the type of users and buyers we are targeting," he said.

Expressions of interest close on October 3.

The history of Rosemount Estate

In 1969, Robert Oatley bought 607 hectares of Denman grazing land that, between 1860 and 1920, contained the Rosemount vineyard planted by German immigrant Carl Brecht.

Mr Oatley aimed to use the land to raise cattle and thoroughbred horses and grow grapes to sell to Hunter wineries.

Instead, he went on to make and market wine under his own Rosemount label.

Rosemount grew into Australia's biggest family-owned wine producer, credited with helping lead an Australian wine boom in the US in the 1990s.

In 2001, the Oatley family company sold Rosemount to Southcorp Wines Ltd for around $1.5 billion, which later merged with Foster's.

The merger led to the winery, restaurant, and cellar door closure at Rosemount Estate.

In 2010, Foster's sold the site at Denman to the company UHI, owned by Mr Wheeldon.

Mr Oatley, a billionaire businessman, vigneron and Wild Oats yachtsman, was named an Officer of the Order of Australia (AO) for "distinguished service to the Australian wine and tourism industries [and] to the sport of yacht racing" in 2014.

He died at 87 in January 2016.