Three teenagers have died in a devastating multi-vehicle crash in north Queensland.

The trio were in a green Mazda 2 travelling south on the Mackay Ring Rd at Glenella, a suburb of Mackay, when the vehicle attempted to overtake a semi-trailer late Friday night.

It collided head-on with a Great Wall Cannon travelling in the opposite direction about 10.40pm.

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All three occupants of the Mazda — two 19-year-old boys and a 19-year-old girl — died at the scene.

The driver of the Great Wall, a 29-year-old man from Blacks Beach, was rushed to Mackay Base Hospital in a serious condition.

The 68-year-old male driver of the semi-trailer, from Kelso, escaped injury.

A fourth vehicle, an Isuzu D-Max, veered off the road to avoid the wreck and the driver was not hurt.

There was heavy fog blanketing the 100km/h stretch of road at the time, The Courier Mail reported, potentially adding to the danger.

Investigations are underway.