Multiple people have been injured in a serious crash which occurred at about 4.50pm on Saturday.

One seriously injured woman was trapped in her vehicle following the three-car smash at the intersection of Argyle St and O’Connell St at Parramatta, in Western Sydney.

She remained at the scene, while paramedics transport three others to Westmead Hospital, NSW Ambulance said.

Five people were injured in total, with four of the patients being treated for minor injuries.

Know the news with the 7NEWS app: Download today

It is understood a man was tackled by police at the scene.