A young bike rider has died in NSW after sustaining serious injuries in a collision with a car.

Emergency services were called to the intersection of Hickey and Limerick St, Coonamble, following reports of a crash involving a trail bike and Toyota SUV about 5:50pm on Saturday.

Police attended the scene of the collision.

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The bike rider, a 20-year-old man, was treated by paramedics for serious head and arm injuries before being taken to Coonamble Hospital in a serious condition.

He died later in the hospital.

The Toyota driver, a 25-year-old woman, was uninjured and taken to the same hospital for mandatory testing.

Both vehicles have been seized for forensic examination.

A crime scene was established, and police have commenced an investigation into the incident.

Anyone with any information about the crash, or who may have dashcam footage of the incident, is urged to contact police.